I currently use the following parameters and run my processor at 3.75 GHz/1 V using the Stock Cooler.
Mining with this CPU is currently fairly profitable, even in my country where electricity is very expensive.
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Threads = 16 PrimeTableLimit = 8589934592 SieveWorkers = 3 SieveBits = 25 # EnableAVX2 = Yes
AVX2 increases earnings but is less profitable due to the increased power consumption (you could activate if you have free electricity).
You should have 32 GiB of RAM to use such high PrimeTableLimit, and increasing it further will not help much, it seems to be the sweetspot.